Fragile-X+Syndrome

 The repeat causes a protein to stop being created which is required for normal brain development. The inherritence of the diseaseis complicated.The mutation process involves several repeating DNA bases on the gene. A gene with 29-31 CGG repeats is normal and not affected. 55-200 repeats is premutation.( premutations passed on in an egg can or can not develop into full mutation.) Over 200 CGG repets is full mutation and you are effected by Fragile-X. It is usually inherited from a mother. media type="youtube" key="_qRwdnP1r-Y" height="349" width="425"  **// Who does Fragile-X affect and how does it affect their offspring? //**  Fragile-X occurs in all ethnic groups.It affects males more often than females, and the symptoms are milder in women. FXS affects an estimated 1 in 4,000 males and 1in 6,000 females. Aproximatley 1 in 100 to 300 women in the population is a Fragile-X carrier. Males are affected more because they only have one copy of the x chromosome and are symptomatic. Since females have 2 copies of the chromosome, if one is affected the other can serve as a backup chromosome. Males can't give the mutation to their sons because they only contribute a y chromosome. They give it to all of their daughters since they give and x chromosome. Females who carry on copy of the Fragile-X syndrome can give both son and daughters the mutation so they have a 50% chance of having FXS. The sons are at higher risk, but the daughters may seem normal with minor intelectual problems.
 * ﻿ Fragile- X Syndrome**  **by Natalie Z**   **//What is Fragile-X Syndrome, and what is it caused by?//**    Fragile-X is the most commonly inherrited form of Mental Retardation or X- Linked Thalassemia. Fragile-X is also known as FXS and Martin-Bell syndrome. It is an X- linked condition caused by mutation on a gene on the x chromosome ** . ** FXS occurs when there are repeats of the tri-nucleotide CGG on the X chromosome.



**this diagram explains how it is passed down. ** //**What are the signs and symptoms of Fragile-X syndrome? **// The signs and symptoms of FXS are elongated face, large ears, low muscle tone, and double- jointed thumbs. Males have large testes after puberty. Flat feet and soft skin are also common.Others are shyness, limited eye-contact, hand-flapping and memory problems. People with Fragile-X often fall into the diagnostic category for autism. FXS causes problems with face encoding, which means they can't recognize faces that they've already seen. People with Fragile-X have mood-swings, high anxiety and have a better chance of developing ADHD and OCD. Children with FXS are usually very hyperactive and are extremeley sensitive to loud noises, touch and more. - UNFORTUNATLEY THERE IS NO CURE FOR FRAGILE-X, THE BEST THING YOU CAN DO IS CATCH IT AT A YOUNG AGE.

These boys have FXS. This video is a great summary of the syndrome:media type="youtube" key="Symw0nU7Hys" height="349" width="425" ﻿  My information is from: [] []

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